Databases and Datasets

ICLAC Register of Misidentified Cell Lines

This resource lists cell lines that are currently known to be cross-contaminated or otherwise misidentified, and is curated by the International Cell Line Authentication Committee. The dataset has its own page with more information here.

Online Databases of Human Cell Line STR Profiles

These databases contain human cell line STR profiles and are essential resources when authenticating human cell lines. For more information, see the reference below or ICLAC’s Guide to Human Cell Line Authentication.

ATCC STR profile database (search and compare STR profiles, login required)
DSMZ STR profile database (search and compare STR profiles, login required)
CLIMA database (search and compare STR profiles, version 2.1)
Cellosaurus database (search cell line name or description)
NCBI BioSample database (search cell line name or description)

Dirks WG, MacLeod RA, Nakamura Y, Kohara A, Reid Y, Milch H, Drexler HG, Mizusawa H (2010) Cell line cross-contamination initiative: an interactive reference database of STR profiles covering common cancer cell lines.  Int J Cancer 126: 303-4.  PMID: 19859913.

Publications or Websites with Cell Line STR and SNP Data

These publications and websites contain STR profiles and/or SNP data from large cell line panels.

COSMIC Cell Lines Project – QC spreadsheet
http://cancer.sanger.ac.uk/cancergenome/projects/cell_lines/about

Gazdar AF, Girard L, Lockwood WW, Lam WL, Minna JD (2010) Lung cancer cell lines as tools for biomedical discovery and research. J Natl Cancer Inst 102: 1310-21. PMID: 20679594.

Liang-Chu MM, Yu M, Haverty PM, Koeman J, Ziegle J, Lee M, Bourgon R, Neve RM (2015) Human Biosample Authentication Using the High-Throughput, Cost-Effective SNPtraceTM System. PLoS One 10: e0116218. PMID: 25714623.

Lorenzi PL, Reinhold WC, Varma S, Hutchinson AA, Pommier Y, Chanock SJ, Weinstein JN (2009) DNA fingerprinting of the NCI-60 cell line panel. Mol Cancer Ther 8: 713-24. PMID: 19372543.

Yu M, Selvaraj SK, Liang-Chu MMY, Aghajani S, Busse M, Yuan J, Lee G, Peale F, Klijn C, Bourgon R, Kaminker JS, Neve RM (2015) A resource for cell line authentication, annotation and quality control. Nature 520: 307-11. PMID: 25877200.

Publications or Websites with Cell Line Names

These publications and websites contain information on cell line names and descriptions.

Cell Line Ontology (CLO)
http://www.clo-ontology.org/

Cellosaurus – a knowledge resource on cell lines
http://web.expasy.org/cellosaurus/

Human Pluripotent Stem Cell Registry (hPSCreg)
http://hpscreg.eu/

HyperCLDB
http://bioinformatics.hsanmartino.it/hypercldb/

Yu M, Selvaraj SK, Liang-Chu MMY, Aghajani S, Busse M, Yuan J, Lee G, Peale F, Klijn C, Bourgon R, Kaminker JS, Neve RM (2015) A resource for cell line authentication, annotation and quality control. Nature 520: 307-11. PMID: 25877200.