Databases and Datasets

ICLAC Register of Misidentified Cell Lines

This resource lists cell lines that are currently known to be cross-contaminated or otherwise misidentified, and is curated by the International Cell Line Authentication Committee. The dataset has its own page with more information here.

Online Databases of Human Cell Line STR Profiles

These databases contain human cell line STR profiles and are essential resources when authenticating human cell lines. For more information, see the links and references that are listed below.

ATCC STR profile database (search and compare STR profiles, login required)
Cellosaurus – a knowledge resource on cell lines (search cell line name or description)
CLASTR: the Cellosaurus STR similarity search tool (search and compare STR profiles)
CLIMA database (search and compare STR profiles, version 2.1)
DSMZ STR profile database (search and compare STR profiles, login required)
NCBI BioSample database (search cell line name or description)

Dirks WG, MacLeod RA, Nakamura Y, Kohara A, Reid Y, Milch H, Drexler HG, Mizusawa H (2010) Cell line cross-contamination initiative: an interactive reference database of STR profiles covering common cancer cell lines.  Int J Cancer 126: 303-4.  PMID: 19859913.

Robin T, Capes-Davis A, Bairoch A (2019) CLASTR: the Cellosaurus STR similarity search tool, a precious help for cell line authentication.  Int J Cancer, Epub 24 August. PMID: 31444973.

Publications or Websites with Cell Line STR and SNP Data

These publications and websites contain STR profiles and/or SNP data from large cell line panels.

COSMIC Cell Lines Project – QC spreadsheet
http://cancer.sanger.ac.uk/cancergenome/projects/cell_lines/about

Gazdar AF, Girard L, Lockwood WW, Lam WL, Minna JD (2010) Lung cancer cell lines as tools for biomedical discovery and research. J Natl Cancer Inst 102: 1310-21. PMID: 20679594.

Liang-Chu MM, Yu M, Haverty PM, Koeman J, Ziegle J, Lee M, Bourgon R, Neve RM (2015) Human Biosample Authentication Using the High-Throughput, Cost-Effective SNPtraceTM System. PLoS One 10: e0116218. PMID: 25714623.

Lorenzi PL, Reinhold WC, Varma S, Hutchinson AA, Pommier Y, Chanock SJ, Weinstein JN (2009) DNA fingerprinting of the NCI-60 cell line panel. Mol Cancer Ther 8: 713-24. PMID: 19372543.

Yu M, Selvaraj SK, Liang-Chu MMY, Aghajani S, Busse M, Yuan J, Lee G, Peale F, Klijn C, Bourgon R, Kaminker JS, Neve RM (2015) A resource for cell line authentication, annotation and quality control. Nature 520: 307-11. PMID: 25877200.

Publications or Websites with Cell Line Names

These publications and websites contain information on cell line names and descriptions.

Cell Line Ontology (CLO)
http://www.clo-ontology.org/

Cellosaurus – a knowledge resource on cell lines
http://web.expasy.org/cellosaurus/

Human Pluripotent Stem Cell Registry (hPSCreg)
http://hpscreg.eu/

HyperCLDB
http://bioinformatics.hsanmartino.it/hypercldb/

Bairoch A (2018) The Cellosaurus, a cell-line knowledge resource. J Biomol Tech 29: 25-38. PMID: 29805321.

Kurtz A, Seltmann S, Bairoch A, Bittner MS, Bruce K, Capes-Davis A, Clarke L, Crook JM, Daheron L, Dewender J, Faulconbridge A, Fujibuchi W, Gutteridge A, Hei DJ, Kim YO, Kim JH, Kokocinski AK, Lekschas F, Lomax GP, Loring JF, Ludwig T, Mah N, Matsui T, Müller R, Parkinson H, Sheldon M, Smith K, Stachelscheid H, Stacey G, Streeter I, Veiga A, Xu RH (2018) A standard nomenclature for referencing and authentication of pluripotent stem cells. Stem Cell Reports 10: 1-6. PMID: 29320760.

Yu M, Selvaraj SK, Liang-Chu MMY, Aghajani S, Busse M, Yuan J, Lee G, Peale F, Klijn C, Bourgon R, Kaminker JS, Neve RM (2015) A resource for cell line authentication, annotation and quality control. Nature 520: 307-11. PMID: 25877200.